Vancomycin`

Vancomycin

Mechanism of action

Inhibits cell wall synthesis BACERICIDAL

( Except Vs streptococci Bacteriostatic )



Antibacterial activity

- Effective mainly vs G+ve bacteria (especially staph)

- Effective on anerobic G+ve

- NOT effective vs G-ve bacteria

- Given with

( streptomycin + gentamycin ) Vs E.faecalis



Pharmacokinetics

- Not absorbed from GIT

given I.V

- Widely distributed

except to CSF

- Only 10 % bound

- Excreted unchanged

in urine

- T1/2 = 8 hours



Clinical uses

- Staph infections not responding to other

anti-biotics

- Serious infections by MRSA and MRSE

- Antibiotics-associated colitis ( ACC ) orally

- Prophylaxis for endocarditis

- prophylaxis for major

surgical procedures



Adverse effects

- GIT upset

- Fever , rashes

- Thrombophilibitis

- Ototoxicity & nephrotoxicity

- Red man

( red neck syndrome)

- Hypersensitivity